Dishonesty in scientific research
Dishonesty is part of the human condition. In this article the authors discuss how dishonesty is rationalized, what …
This article is part of the RIAT initiative (Restoring Invisible and Abandoned Trials) and aims to restore the misreported trial that is known as Study 329, funded by SmithKline Beecham (subsequently GlaxoSmithKline). In contrary to the conclusions stated in the original article, these authors found neither clinically relevant nor statistically significant differences in the primary and secondary outcomes between placebo and the drugs under investigation (paroxetine and imipramine). However, clinically relevant increases in harms were found!
Title: Restoring Study 329: efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence
Authors: Le Noury J, Nardo JM, Healy D, Jureidin J, Raven M, Tufanaru C, Abi-Jaoude E
doi: 10.1136/bmj.h4320 (2015)
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