The SIENNA project is an European Commission-funded project in the Horizon 2020 programme with a budget of € 4.0 million and a running time of 3 ½ years (October 1, 2017 – April 1, 2021). It is carried by a consortium of thirteen organizations from the European Union and other parts of the world. It aims to promote enhanced consideration of ethical and human rights issues in new and emerging technologies with major socio-economic impact and human rights relevance. To this effect, it will produce a stakeholder-informed ethical, legal and human-rights analysis of three such technologies: human genomics, human enhancement and human-machine interaction technologies (including robotics, artificial agents, smart environments and others). It will subsequently develop, with stakeholders, new ethics guidelines and codes and proposals for amending existing ethical and legal frameworks to accommodate for the issues raised by these technologies. The analysis will be based on research and coordination and support actions carried out by the partners.